Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.
Identifieur interne : 000962 ( Main/Exploration ); précédent : 000961; suivant : 000963Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.
Auteurs : Vasiliki I. Dimitrakopoulou [Grèce] ; Ruth C. Travis [Royaume-Uni] ; Irene M. Shui [États-Unis] ; Alison Mondul [États-Unis] ; Demetrius Albanes [États-Unis] ; Jarmo Virtamo [Finlande] ; Antonio Agudo [Espagne] ; Heiner Boeing [Allemagne] ; H Bas Bueno-De-Mesquita [Royaume-Uni] ; Marc J. Gunter [France] ; Mattias Johansson [Suède] ; Kay-Tee Khaw [Royaume-Uni] ; Kim Overvad [Danemark] ; Domenico Palli [Italie] ; Antonia Trichopoulou [Grèce] ; Edward Giovannucci [États-Unis] ; David J. Hunter [Australie] ; Sara Lindström [États-Unis] ; Walter Willett [États-Unis] ; J Michael Gaziano [États-Unis] ; Meir Stampfer [États-Unis] ; Christine Berg [Allemagne] ; Sonja I. Berndt [États-Unis] ; Amanda Black [États-Unis] ; Robert N. Hoover [États-Unis] ; Peter Kraft [États-Unis] ; Timothy J. Key [Royaume-Uni] ; Konstantinos K. Tsilidis [Royaume-Uni]Source :
- American journal of epidemiology [ 1476-6256 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Facteurs de protection, Génotype, Humains, Interaction entre gènes et environnement, Modèles logistiques, Mâle, Polymorphisme de nucléotide simple, Sujet âgé, Tumeurs de la prostate (), Tumeurs de la prostate (génétique), Tumeurs de la prostate (mortalité), Tumeurs de la prostate (sang), Vitamine D (analogues et dérivés), Vitamine D (génétique), Vitamine D (sang), Étude d'association pangénomique, Études cas-témoins, Évaluation des risques.
- MESH :
- analogues et dérivés : Vitamine D.
- génétique : Tumeurs de la prostate, Vitamine D.
- mortalité : Tumeurs de la prostate.
- sang : Tumeurs de la prostate, Vitamine D.
- Adulte d'âge moyen, Facteurs de protection, Génotype, Humains, Interaction entre gènes et environnement, Modèles logistiques, Mâle, Polymorphisme de nucléotide simple, Sujet âgé, Tumeurs de la prostate, Étude d'association pangénomique, Études cas-témoins, Évaluation des risques.
English descriptors
- KwdEn :
- Aged, Case-Control Studies, Gene-Environment Interaction, Genome-Wide Association Study, Genotype, Humans, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Prostatic Neoplasms (blood), Prostatic Neoplasms (genetics), Prostatic Neoplasms (mortality), Prostatic Neoplasms (prevention & control), Protective Factors, Risk Assessment, Vitamin D (analogs & derivatives), Vitamin D (blood), Vitamin D (genetics).
- MESH :
- chemical , analogs & derivatives : Vitamin D.
- blood : Prostatic Neoplasms, Vitamin D.
- genetics : Prostatic Neoplasms, Vitamin D.
- mortality : Prostatic Neoplasms.
- prevention & control : Prostatic Neoplasms.
- Aged, Case-Control Studies, Gene-Environment Interaction, Genome-Wide Association Study, Genotype, Humans, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Protective Factors, Risk Assessment.
Abstract
Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyvitamin D (25(OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls-from 5 cohort studies that recruited participants over several periods beginning in the 1980s). We used logistic regression models with data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) to evaluate interactions on the multiplicative and additive scales. After allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these concentrations. A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≤ 0.001). We did not find strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.
DOI: 10.1093/aje/kww143
PubMed: 28399564
Affiliations:
- Allemagne, Australie, Danemark, Espagne, Finlande, France, Grèce, Italie, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Auvergne-Rhône-Alpes, Catalogne, District de Cologne, Grand Londres, Illinois, Maryland, Massachusetts, Michigan, Oxfordshire, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Washington (État)
- Athènes, Barcelone, Bonn, Cambridge, Londres, Lyon, Oxford, Seattle
- Université d'Oxford, Université de Cambridge, Université de Washington
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Le document en format XML
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Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Aging, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Berg, Christine" sort="Berg, Christine" uniqKey="Berg C" first="Christine" last="Berg">Christine Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892</wicri:regionArea><wicri:noRegion>20892</wicri:noRegion></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation wicri:level="2"><nlm:affiliation>Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>University of Washington and Harvard T.H. Chan School of Public Health, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington and Harvard T.H. Chan School of Public Health, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28399564</idno><idno type="pmid">28399564</idno><idno type="doi">10.1093/aje/kww143</idno><idno type="wicri:Area/PubMed/Corpus">000F04</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F04</idno><idno type="wicri:Area/PubMed/Curation">000F01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F01</idno><idno type="wicri:Area/PubMed/Checkpoint">000F01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F01</idno><idno type="wicri:Area/Ncbi/Merge">004622</idno><idno type="wicri:Area/Ncbi/Curation">004622</idno><idno type="wicri:Area/Ncbi/Checkpoint">004622</idno><idno type="wicri:Area/Main/Merge">000957</idno><idno type="wicri:Area/Main/Curation">000962</idno><idno type="wicri:Area/Main/Exploration">000962</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interactions Between Genome-Wide Significant Genetic Variants and Circulating Concentrations of 25-Hydroxyvitamin D in Relation to Prostate Cancer Risk in the National Cancer Institute BPC3.</title><author><name sortKey="Dimitrakopoulou, Vasiliki I" sort="Dimitrakopoulou, Vasiliki I" uniqKey="Dimitrakopoulou V" first="Vasiliki I" last="Dimitrakopoulou">Vasiliki I. Dimitrakopoulou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Stavros Niarchos Avenue, University Campus, Ioannina, Greece</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Stavros Niarchos Avenue, University Campus, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Shui, Irene M" sort="Shui, Irene M" uniqKey="Shui I" first="Irene M" last="Shui">Irene M. Shui</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Mondul, Alison" sort="Mondul, Alison" uniqKey="Mondul A" first="Alison" last="Mondul">Alison Mondul</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology,University of Michigan School of Public Health,Ann Arbor, MI,USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology,University of Michigan School of Public Health,Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare (THL), Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name><affiliation wicri:level="3"><nlm:affiliation>Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology,German Institute of Human Nutrition Potsdam-Rehbruecke,14558 Nuthetal,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology,German Institute of Human Nutrition Potsdam-Rehbruecke,14558 Nuthetal</wicri:regionArea><wicri:noRegion>14558 Nuthetal</wicri:noRegion><wicri:noRegion>14558 Nuthetal</wicri:noRegion><wicri:noRegion>14558 Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07, Uppsala, SE, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07, Uppsala, SE</wicri:regionArea><wicri:noRegion>SE</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health and Primary Care, University of Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Public Health and Primary Care, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Public Health, Section for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C</wicri:regionArea><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Risk Factors and Life-Style Epidemiology Unit,Cancer Research and Prevention Institute (ISPO),50141 Florence,Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Risk Factors and Life-Style Epidemiology Unit,Cancer Research and Prevention Institute (ISPO),50141 Florence</wicri:regionArea><wicri:noRegion>50141 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="3"><nlm:affiliation>Hellenic Health Foundation,GR-115 27, Athens,Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation,GR-115 27, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rheumatology, Royal North Shore Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Washington</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><affiliation wicri:level="2"><nlm:affiliation>Aging, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Aging, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Berg, Christine" sort="Berg, Christine" uniqKey="Berg C" first="Christine" last="Berg">Christine Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892</wicri:regionArea><wicri:noRegion>20892</wicri:noRegion></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation wicri:level="2"><nlm:affiliation>Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>University of Washington and Harvard T.H. Chan School of Public Health, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Washington and Harvard T.H. Chan School of Public Health, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation wicri:level="3"><nlm:affiliation>School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">American journal of epidemiology</title><idno type="eISSN">1476-6256</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Gene-Environment Interaction</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Prostatic Neoplasms (blood)</term><term>Prostatic Neoplasms (genetics)</term><term>Prostatic Neoplasms (mortality)</term><term>Prostatic Neoplasms (prevention & control)</term><term>Protective Factors</term><term>Risk Assessment</term><term>Vitamin D (analogs & derivatives)</term><term>Vitamin D (blood)</term><term>Vitamin D (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de protection</term><term>Génotype</term><term>Humains</term><term>Interaction entre gènes et environnement</term><term>Modèles logistiques</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Tumeurs de la prostate ()</term><term>Tumeurs de la prostate (génétique)</term><term>Tumeurs de la prostate (mortalité)</term><term>Tumeurs de la prostate (sang)</term><term>Vitamine D (analogues et dérivés)</term><term>Vitamine D (génétique)</term><term>Vitamine D (sang)</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Prostatic Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Prostatic Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs de la prostate</term><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs de la prostate</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tumeurs de la prostate</term><term>Vitamine D</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Gene-Environment Interaction</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Protective Factors</term><term>Risk Assessment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de protection</term><term>Génotype</term><term>Humains</term><term>Interaction entre gènes et environnement</term><term>Modèles logistiques</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Tumeurs de la prostate</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyvitamin D (25(OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls-from 5 cohort studies that recruited participants over several periods beginning in the 1980s). We used logistic regression models with data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) to evaluate interactions on the multiplicative and additive scales. After allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these concentrations. A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≤ 0.001). We did not find strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Catalogne</li><li>District de Cologne</li><li>Grand Londres</li><li>Illinois</li><li>Maryland</li><li>Massachusetts</li><li>Michigan</li><li>Oxfordshire</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li><li>Washington (État)</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Bonn</li><li>Cambridge</li><li>Londres</li><li>Lyon</li><li>Oxford</li><li>Seattle</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Cambridge</li><li>Université de Washington</li></orgName></list><tree><country name="Grèce"><noRegion><name sortKey="Dimitrakopoulou, Vasiliki I" sort="Dimitrakopoulou, Vasiliki I" uniqKey="Dimitrakopoulou V" first="Vasiliki I" last="Dimitrakopoulou">Vasiliki I. Dimitrakopoulou</name></noRegion><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name></region><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Shui, Irene M" sort="Shui, Irene M" uniqKey="Shui I" first="Irene M" last="Shui">Irene M. Shui</name></region><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><name sortKey="Mondul, Alison" sort="Mondul, Alison" uniqKey="Mondul A" first="Alison" last="Mondul">Alison Mondul</name><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name></country><country name="Finlande"><noRegion><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name></region></country><country name="Allemagne"><noRegion><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name></noRegion><name sortKey="Berg, Christine" sort="Berg, Christine" uniqKey="Berg C" first="Christine" last="Berg">Christine Berg</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name></region></country><country name="Suède"><noRegion><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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